Auntie: My niece is interested in applying, but she may get an F in Calculus this year. Will that affect her chances of being admitted?
Me: Good question...one F on a transcript isn't going to be a decision maker here--while I would encourage her to retake the class for a better grade, the overall GPA is much more important than one grade.
Auntie: Oh, ok...so her overall GPA is...pretty low. Will that affect her chances?
YES. Yes. What did you think this was all about??